Circulating neutrophil extracellular traps in cats with hypertrophic cardiomyopathy and cardiogenic arterial thromboembolism.

ABSTRACT:

Background

Cats with hypertrophic cardiomyopathy (HCM) are at risk of cardiogenic arterial thromboembolism (CATE). Neutrophil extracellular traps (NETs) may be a potential biomarker and therapeutic target for cardiomyopathy in cats.

Hypothesis/objectives

Characterize NETs in cats with HCM or CATE. We hypothesized that circulating NETs assessed in the form of cell-free DNA (cfDNA) and citrullinated histone H3 (citH3) are increased in cats with HCM and CATE and associated with reported predisposing factors for thrombus formation.

Animals

Eighty-five cats including client-owned cats with HCM and CATE and staff- and student-owned clinically healthy cats without HCM.

Methods

After echocardiographic evaluations, NETs were measured as cfDNA and citH3.

Results

C

SUBMITTER: Li RHL 

PROVIDER: S-EPMC10061180 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature