Food-inspired peptides from spinach Rubisco endowed with antioxidant, antinociceptive and anti-inflammatory properties

ABSTRACT: Highlights • Rubiscolin-6 is a linear peptide isolated by the spinach Rubisco.• New analogues have been prepared via SPPS with high purity and good overall yields.• Their activity on opioid receptors has been detected in vitro and in vivo.• Some of them possess a strong antioxidant and tyrosinase inhibitor activity.• Peptide LMAS6 exerts also a significant anti-inflammatory in vivo. Rubiscolin-6 (amino acid sequence: YPLDLF) is a selective δ-opioid receptor peptide isolated from spinach Rubisco. Its synthetic analogue, peptide YPMDIV is the most potent described so far for its increased opioid activity, thus in this work it was considered as lead compound for the design of twelve new analogues e.g.LMAS1-12. Firstly all the novel compounds have been tested for their antinociceptive and anti

SUBMITTER: Marinaccio L 

PROVIDER: S-EPMC10064441 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature