Recent advances in prostate cancer: WNT signaling, chromatin regulation, and transcriptional coregulators.

ABSTRACT: Prostate cancer is one of the most common diseases in men worldwide. Surgery, radiation therapy, and hormonal therapy are effective treatments for early-stage prostate cancer. However, the development of castration-resistant prostate cancer has increased the mortality rate of prostate cancer. To develop novel drugs for castration-resistant prostate cancer, the molecular mechanisms of prostate cancer progression must be elucidated. Among the signaling pathways regulating prostate cancer development, recent studies have revealed the importance of noncanonical wingless-type MMTV integration site family (WNT) signaling pathways, mainly that involving WNT5A, in prostate cancer progression and metastasis; however, its role remains controversial. Moreover, chromatin remodelers such as the switch/

SUBMITTER: Takahashi S 

PROVIDER: S-EPMC10069695 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature