A life course approach to understanding stress exposures and cognitive function among middle-aged and older adults.

ABSTRACT:

Background

Many studies have evaluated the stress-cognition association, but few have captured the cumulative nature of stress or distinguished the influences of stressors occurring in childhood versus adulthood. Using a lifecourse approach, we investigated whether cumulative stress exposures are associated with poorer cognitive function and faster cognitive decline.

Methods

We used data from the Midlife Development in the United States Study (N = 3,954, mean baseline age: 56 years). We fit marginal structural generalized estimating equations models to estimate the difference in baseline cognitive function per SD increment in the continuous stressor score, and, separately, between persons in each life course stressor profile and those who did not experience high stress in ei

SUBMITTER: Chen R 

PROVIDER: S-EPMC10069937 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature