Dendritic cells drive profibrotic inflammation and aberrant T cell polarization in systemic sclerosis.

ABSTRACT:

Objectives

SSc is a devastating autoimmune disease characterized by fibrosis and obliterative vasculopathy affecting the skin and visceral organs. While the processes mediating excessive extracellular matrix deposition and fibroblast proliferation are clear, the exact link between autoimmunity and fibrosis remains elusive. Th17 cells have been proposed as critical drivers of profibrotic inflammation during SSc, but little is known about the immune components supporting their pathogenic role. Our aim was to determine cytokine responses of stimulated monocyte-derived dendritic cells (Mo-DCs) and to determine how they influence T-cell cytokine production in SSc.

Material and methods

Dendritic cells (DCs) activate and shape T cell differentiation by producing polarizing cytokine

SUBMITTER: Choreno-Parra JA 

PROVIDER: S-EPMC10070068 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature