A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer.

ABSTRACT:

Background

Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a more refined appreciation of the TIME in childhood cancers, rather than a reliance on commonly used biomarkers such as tumour mutation burden (TMB), neoantigen load and PD-L1 expression, is an essential prerequisite for improved immunotherapies in childhood solid cancers.

Methods

We combined immunohistochemistry (IHC) with RNA sequencing and whole-genome sequencing across a diverse spectrum of high-risk paediatric cancers to develop an alternative, expression-based signature associated with CD8⁺ T-cell infiltration of the TIME.

SUBMITTER: Mayoh C 

PROVIDER: S-EPMC10071693 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature