Dataset Information

Retinal microvascular changes in patients recovered from COVID-19 compared to healthy controls: A meta-analysis.

ABSTRACT:

Purpose

To investigate changes in retinal microcirculation in patients recovered from COVID-19 infection compared to healthy controls, using optical coherence tomography-angiography.

Methods

Meta-analysis of eligible studies comparing retinal microcirculation between patients recovered from COVID-19 infection and healthy controls up to 7th of September 2022 was performed, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2009 guidelines. The following search algorithm was used: (COVID-19 OR coronavirus) AND (retina OR optical coherence tomography OR optical coherence tomography angiography OR vessel density OR foveal avascular zone). Standardized Mean Difference (SMD) with 95% confidence interval (CI) was calculated to compare continuous variables. Revman 5.3 was used for the analysis.

Results

12 studies were included in our analysis. Foveal avascular zone (FAZ) area was larger in patients recovered from COVID-19 infection compared to healthy controls, while there was no statistically significant difference in FAZ perimeter between the two groups. The foveal, parafoveal and whole image vessel density in the superficial capillary plexus showed no significant difference between the two groups. The foveal, parafoveal and whole image vessel density in the deep capillary plexus was statistically lower in patients recovered from COVID-19 compared to healthy controls.

Conclusion

FAZ area was enlarged and foveal, parafoveal and whole image vessel density in deep capillary plexus were reduced in patients recovered from COVID-19 infection compared to healthy controls, suggesting that COVID-19 infection may induce long-term retinal microvascular changes in patients recovered from the virus infection.

SUBMITTER: Kazantzis D

PROVIDER: S-EPMC10072975 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Retinal microvascular changes in patients recovered from COVID-19 compared to healthy controls: A meta-analysis.

Kazantzis Dimitrios D Machairoudia Genovefa G Theodossiadis George G Theodossiadis Panagiotis P Chatziralli Irini I

Photodiagnosis and photodynamic therapy 20230405

<h4>Purpose</h4>To investigate changes in retinal microcirculation in patients recovered from COVID-19 infection compared to healthy controls, using optical coherence tomography-angiography.<h4>Methods</h4>Meta-analysis of eligible studies comparing retinal microcirculation between patients recovered from COVID-19 infection and healthy controls up to 7th of September 2022 was performed, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2009 guidelines. The follo ...[more]

PMID: 37023998

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Dataset Information

Retinal microvascular changes in patients recovered from COVID-19 compared to healthy controls: A meta-analysis.

Purpose

Methods

Results

Conclusion

Publications

Retinal microvascular changes in patients recovered from COVID-19 compared to healthy controls: A meta-analysis.

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