Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice.

ABSTRACT: Information transfer within neuronal circuits depends on the balance and recurrent activity of excitatory and inhibitory neurotransmission. Chloride (Cl^-) is the major central nervous system (CNS) anion mediating inhibitory neurotransmission. Astrocytes are key homoeostatic glial cells populating the CNS, although the role of these cells in regulating excitatory-inhibitory balance remains unexplored. Here we show that astrocytes act as a dynamic Cl^- reservoir regulating Cl^- homoeostasis in the CNS. We found that intracellular chloride concentration ([Cl^-]_i) in astrocytes is high and stable during sleep. In awake mice astrocytic [Cl^-]_i is lower and exhibits large fluctuation in response to both sensory input and mo

SUBMITTER: Untiet V 

PROVIDER: S-EPMC10073105 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature