The association between sex hormones and the change in brain-predicted age difference in older women.

ABSTRACT:

Objective

The role of circulating sex hormones on structural brain ageing is yet to be established. This study explored whether concentrations of circulating sex hormones in older women are associated with the baseline and longitudinal changes in structural brain ageing, defined by the brain-predicted age difference (brain-PAD).

Design

Prospective cohort study using data from NEURO and Sex Hormones in Older Women; substudies of the ASPirin in Reducing Events in the Elderly clinical trial.

Patients

Community-dwelling older women (aged 70+ years).

Measurements

Oestrone, testosterone, dehydroepiandrosterone (DHEA), and sex-hormone binding globulin (SHBG) were quantified from plasma samples collected at baseline. T1-weighted magnetic resonance imaging was performed

SUBMITTER: Wrigglesworth J 

PROVIDER: S-EPMC10073334 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature