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Novel N(SCF3)(CF3)-amines: synthesis, scalability and stability.

ABSTRACT: We disclosed herein a straightforward strategy for the synthesis of unprecedented N-((trifluoromethyl)thio), N-(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the methodology has been demonstrated and the stability of the new motif has been studied.

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10074438 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Novel N(SCF<sub>3</sub>)(CF<sub>3</sub>)-amines: synthesis, scalability and stability.

Yang Yi Y   Saffon-Merceron Nathalie N   Vantourout Julien C JC   Tlili Anis A  

Chemical science 20230313 14

We disclosed herein a straightforward strategy for the synthesis of unprecedented <i>N</i>-((trifluoromethyl)thio), <i>N</i>-(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the methodology has been demonstrated and the stability of the new motif has been studied. ...[more]

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