Effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly-pigmented skin.

ABSTRACT: Lipopolysaccharides (LPS) alter melanin synthesis and induce cytokine secretion in melanocytes; however, effects of different serotypes or species of LPS have been rarely addressed. Herein, LPS from serotypes (O55:B5, O26:B6, O128:B12) of E Coli and P gingivalis (LPS-PG) was examined in human melanocytes of lightly-pigmented (LP) and darkly-pigmented (DP) donors. Results showed no effect of any LPS on melanin production in both cells. B6 and B12 elicited higher levels of IL-6 than B5 in LP cells while B6 was more potent than B12 in DP cells. B5 and PG did not show any effect on IL-6 in both cells.

SUBMITTER: Goenka S 

PROVIDER: S-EPMC10074968 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature