Effect of ultrapure lipopolysaccharides derived from diverse bacterial species on the modulation of platelet activation.

ABSTRACT: Platelets are small circulating blood cells that play essential roles in the maintenance of haemostasis via blood clotting. However, they also play critical roles in the regulation of innate immune responses. Inflammatory receptors, specifically Toll-like receptor (TLR)-4, have been reported to modify platelet reactivity. A plethora of studies have reported controversial functions of TLR4 in the modulation of platelet function using various chemotypes and preparations of its ligand, lipopolysaccharide (LPS). The method of preparation of LPS may explain these discrepancies however this is not fully understood. Hence, to determine the impact of LPS on platelet activation, we used ultrapure preparations of LPS from Escherichia coli (LPS_EC), Salmonella minnesota (LPS_SM),

SUBMITTER: Vallance TM 

PROVIDER: S-EPMC6890654 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature