Inhibiting phosphatase and actin regulator 1 expression is neuroprotective in the context of traumatic brain injury.

ABSTRACT: Studies have found that the phosphatase actin regulatory factor 1 expression can be related to stroke, but it remains unclear whether changes in phosphatase actin regulatory factor 1 expression also play a role in traumatic brain injury. In this study we found that, in a mouse model of traumatic brain injury induced by controlled cortical impact, phosphatase actin regulatory factor 1 expression is increased in endothelial cells, neurons, astrocytes, and microglia. When we overexpressed phosphatase actin regulatory factor 1 by injection an adeno-associated virus vector into the contused area in the traumatic brain injury mice, the water content of the brain tissue increased. However, when phosphatase actin regulatory factor 1 was knocked down, the water content decreased. We also found that

SUBMITTER: Jing Y 

PROVIDER: S-EPMC10075113 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature