Dataset Information

Systematic review of small intestine pacing parameters for modulation of gut function.

ABSTRACT:

Background and purpose

The efficacy of conventional treatments for severe and chronic functional motility disorders remains limited. High-energy pacing is a promising alternative therapy for patients that fail conventional treatment. Pacing primarily regulates gut motility by modulating rhythmic bio-electrical events called slow waves. While the efficacy of this technique has been widely investigated on the stomach, its application in the small intestine is less developed. This systematic review was undertaken to summarize the status of small intestinal pacing and evaluate its efficacy in modulating bowel function through preclinical research studies.

Methods

The literature was searched using Scopus, PubMed, Ovid, Cochrane, CINAHL, and Google Scholar. Studies investigating electrophysiological, motility, and/or nutrient absorption responses to pacing were included. A critical review of all included studies was conducted comparing study outcomes against experimental protocols.

Results

The inclusion criteria were met by 34 publications. A range of pacing parameters including amplitude, pulse width, pacing direction, and its application to broad regional small intestinal segments were identified and assessed. Out of the 34 studies surveyed, 20/23 studies successfully achieved slow-wave entrainment, 9/11 studies enhanced nutrient absorption and 21/27 studies modulated motility with pacing.

Conclusion

Small intestine pacing shows therapeutic potential in treating disorders such as short bowel syndrome and obesity. This systematic review proposes standardized protocols to maximize research outcomes and thereby translate to human studies for clinical validation. The use of novel techniques such as high-resolution electrical, manometric, and optical mapping in future studies will enable a mechanistic understanding of pacing.

SUBMITTER: Nagahawatte ND

PROVIDER: S-EPMC10078404 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Systematic review of small intestine pacing parameters for modulation of gut function.

Nagahawatte Nipuni D ND Cheng Leo K LK Avci Recep R Angeli-Gordon Timothy R TR Paskaranandavadivel Niranchan N

Neurogastroenterology and motility 20221004 1

<h4>Background and purpose</h4>The efficacy of conventional treatments for severe and chronic functional motility disorders remains limited. High-energy pacing is a promising alternative therapy for patients that fail conventional treatment. Pacing primarily regulates gut motility by modulating rhythmic bio-electrical events called slow waves. While the efficacy of this technique has been widely investigated on the stomach, its application in the small intestine is less developed. This systemati ...[more]

PMID: 36194179

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Dataset Information

Systematic review of small intestine pacing parameters for modulation of gut function.

Background and purpose

Methods

Results

Conclusion

Publications

Systematic review of small intestine pacing parameters for modulation of gut function.

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