Prion infection modulates hematopoietic stem/progenitor cell fate through cell-autonomous and non-autonomous mechanisms.

ABSTRACT: Studies of PrP^C-derived prion disease generally focus on neurodegeneration. However, little is known regarding the modulation of hematopoietic stem progenitor cells (HSPCs) that express PrP^C in prion infection. Among bone marrow (BM) hematopoietic cells, hematopoietic stem cells (HSCs) strongly express PrP^C. A bioassay revealed the presence of misfolded prion protein (PrP^Sc) in BM cells derived from prion-infected mice; these BM cells demonstrated reproducible prion infectivity. At 5 months after infection with ME7, mice exhibited a significant decrease in the number of HSPCs. This decrease was mainly driven by increased apoptotic cell death, rather than cell cycle progression and senescence, in PrP^C-positive but not PrP^C-ne

SUBMITTER: Sim HJ 

PROVIDER: S-EPMC10079512 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature