Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort.

ABSTRACT:

Background

Many psychiatric outcomes are thought to share a common etiological pathway reflecting behavioral disinhibition, generally referred to as externalizing disorders (EXT). Recent genome-wide association studies (GWAS) have demonstrated the overlap between EXT and important aspects of veterans' health, such as suicide-related behaviors, substance use disorders, and other medical conditions.

Methods

We conducted a series of phenome-wide association studies (PheWAS) of polygenic scores (PGS) for EXT, and comorbid psychiatric problems (depression, schizophrenia, and suicide attempt) in an ancestrally diverse cohort of U.S. veterans (N = 560,824), using diagnostic codes from electronic health records. We conducted ancestry-specific PheWASs of EXT PGS in the Europea

SUBMITTER: Barr PB 

PROVIDER: S-EPMC10081391 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature