Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.

ABSTRACT: Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetr

SUBMITTER: Schijven D 

PROVIDER: S-EPMC10083554 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature