Dataset Information

Long-term cardiovascular mortality in women with twin pregnancies by lifetime reproductive history.

ABSTRACT:

Background

Women with one lifetime singleton pregnancy have increased risk of cardiovascular disease (CVD) mortality compared with women who continue reproduction particularly if the pregnancy had complications. Women with twins have higher risk of pregnancy complications, but CVD mortality risk in women with twin pregnancies has not been fully described.

Objectives

We estimated risk of long-term CVD mortality in women with naturally conceived twins compared to women with singleton pregnancies, accounting for lifetime number of pregnancies and pregnancy complications.

Methods

Using linked data from the Medical Birth Registry of Norway and the Norwegian Cause of Death Registry, we identified 974,892 women with first pregnancy registered between 1967 and 2013, followed to 2020. Adjusted hazard ratios (aHR) with 95% confidence intervals (CI) for maternal CVD mortality were estimated by Cox regression for various reproductive history (exposure categories): (1) Only one twin pregnancy, (2) Only one singleton pregnancy, (3) Only two singleton pregnancies, (4) A first twin pregnancy and continued reproduction, (5) A first singleton pregnancy and twins in later reproduction and (6) Three singleton pregnancies (the referent group). Exposure categories were also stratified by pregnancy complications (pre-eclampsia, preterm delivery or perinatal loss).

Results

Women with one lifetime pregnancy, twin or singleton, had increased risk of CVD mortality (adjusted hazard [HR] 1.72, 95% confidence interval [CI] 1.21, 2.43 and aHR 1.92, 95% CI 1.78, 2.07, respectively), compared with the referent of three singleton pregnancies. The hazard ratios for CVD mortality among women with one lifetime pregnancy with any complication were 2.36 (95% CI 1.49, 3.71) and 3.56 (95% CI 3.12, 4.06) for twins and singletons, respectively.

Conclusions

Women with only one pregnancy, twin or singleton, had increased long-term CVD mortality, however highest in women with singletons. In addition, twin mothers who continued reproduction had similar CVD mortality compared to women with three singleton pregnancies.

SUBMITTER: Basnet P

PROVIDER: S-EPMC10087704 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Long-term cardiovascular mortality in women with twin pregnancies by lifetime reproductive history.

Basnet Prativa P Skjaerven Rolv R Sørbye Linn Marie LM Morken Nils-Halvdan NH Klungsøyr Kari K Singh Aditi A Mannseth Janne J Harmon Quaker E QE Kvalvik Liv Grimstvedt LG

Paediatric and perinatal epidemiology 20220929 1

<h4>Background</h4>Women with one lifetime singleton pregnancy have increased risk of cardiovascular disease (CVD) mortality compared with women who continue reproduction particularly if the pregnancy had complications. Women with twins have higher risk of pregnancy complications, but CVD mortality risk in women with twin pregnancies has not been fully described.<h4>Objectives</h4>We estimated risk of long-term CVD mortality in women with naturally conceived twins compared to women with singleto ...[more]

PMID: 36173007

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Dataset Information

Long-term cardiovascular mortality in women with twin pregnancies by lifetime reproductive history.

Background

Objectives

Methods

Results

Conclusions

Publications

Long-term cardiovascular mortality in women with twin pregnancies by lifetime reproductive history.

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