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A review of estimated transmission parameters for the spread of avian influenza viruses.

ABSTRACT: Avian influenza poses an increasing problem in Europe and around the world. Simulation models are a useful tool to predict the spatiotemporal risk of avian influenza spread and evaluate appropriate control actions. To develop realistic simulation models, valid transmission parameters are critical. Here, we reviewed published estimates of the basic reproduction number (R₀ ), the latent period and the infectious period by virus type, pathogenicity, species, study type and poultry flock unit. We found a large variation in the parameter estimates, with highest R₀ estimates for H5N1 and H7N3 compared with other types; for low pathogenic avian influenza compared with high pathogenic avian influenza types; for ducks compared with other species; for estimates from field studies compared with experimental studies; and for within-flock estimates compared with between-flock estimates. Simulation models should reflect this observed variation so as to produce more reliable outputs and support decision-making. How to incorporate this information into simulation models remains a challenge.

SUBMITTER: Kirkeby C

PROVIDER: S-EPMC10088015 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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A review of estimated transmission parameters for the spread of avian influenza viruses.

Kirkeby Carsten C Ward Michael P MP

Transboundary and emerging diseases 20220819 6

Avian influenza poses an increasing problem in Europe and around the world. Simulation models are a useful tool to predict the spatiotemporal risk of avian influenza spread and evaluate appropriate control actions. To develop realistic simulation models, valid transmission parameters are critical. Here, we reviewed published estimates of the basic reproduction number (R<sub>0</sub> ), the latent period and the infectious period by virus type, pathogenicity, species, study type and poultry flock ...[more]

PMID: 35959696

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Project description:Repeated outbreaks due to H3N1 low pathogenicity avian influenza viruses (LPAIV) in Belgium were associated with unusually high mortality in chicken in 2019. Those events caused considerable economic losses and prompted restriction measures normally implemented for eradicating high pathogenicity avian influenza viruses (HPAIV). Initial pathology investigations and infection studies suggested this virus to be able to replicate systemically, being very atypical for H3 LPAIV. Here, we investigate the pathogenesis of this H3N1 virus and propose a mechanism explaining its unusual systemic replication capability. By intravenous and intracerebral inoculation in chicken, we demonstrate systemic spread of this virus, extending to the central nervous system. Endoproteolytic viral hemagglutinin (HA) protein activation by either tissue-restricted serine peptidases or ubiquitous subtilisin-like proteases is the functional hallmark distinguishing (H5 or H7) LPAIV from HPAIV. However, luciferase reporter assays show that HA cleavage in case of the H3N1 strain in contrast to the HPAIV is not processed by intracellular proteases. Yet the H3N1 virus replicates efficiently in cell culture without trypsin, unlike LPAIVs. Moreover, this trypsin-independent virus replication is inhibited by 6-aminohexanoic acid, a plasmin inhibitor. Correspondingly, in silico analysis indicates that plasminogen is recruitable by the viral neuraminidase for proteolytic activation due to the loss of a strongly conserved N-glycosylation site at position 130. This mutation was shown responsible for plasminogen recruitment and neurovirulence of the mouse brain-passaged laboratory strain A/WSN/33 (H1N1). In conclusion, our findings provide good evidence in natural chicken strains for N1 neuraminidase-operated recruitment of plasminogen, enabling systemic replication leading to an unusual high pathogenicity phenotype. Such a gain of function in naturally occurring AIVs representing an established human influenza HA-subtype raises concerns over potential zoonotic threats.

Dataset Information

A review of estimated transmission parameters for the spread of avian influenza viruses.

Publications

A review of estimated transmission parameters for the spread of avian influenza viruses.

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