Identification of shared fatty acid metabolism related signatures in dilated cardiomyopathy and myocardial infarction.

ABSTRACT:

Aim

It is to be elucidated the risk-predictive role of differentially expressed fatty acid metabolism related genes (DE-FRGs) in dilated cardiomyopathy (DCM) and myocardial infarction.

Materials & methods

Four gene enrichment analyses defined DE-FRGs' biological functions and pathways. Three strategies were applied to identify risk biomarkers and construct a nomogram. The 4-DE-FRG correlation with immune cell infiltration, drugs, and ceRNA was explored.

Results

DE-FRGs were enriched in lipid metabolism. A risk nomogram was established by ACSL1, ALDH2, CYP27A1 and PPARA, demonstrating a good ability for DCM and myocardial infarction prediction. PPARA was positively correlated with adaptive immunocytes. Thirty-five drugs are candidate therapeutic ta

SUBMITTER: Huang B 

PROVIDER: S-EPMC10088053 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature