Dataset Information
Identification of shared fatty acid metabolism related signatures in dilated cardiomyopathy and myocardial infarction.
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ABSTRACT: Aim
It is to be elucidated the risk-predictive role of differentially expressed fatty acid metabolism related genes (DE-FRGs) in dilated cardiomyopathy (DCM) and myocardial infarction.Materials & methods
Four gene enrichment analyses defined DE-FRGs' biological functions and pathways. Three strategies were applied to identify risk biomarkers and construct a nomogram. The 4-DE-FRG correlation with immune cell infiltration, drugs, and ceRNA was explored.Results
DE-FRGs were enriched in lipid metabolism. A risk nomogram was established by ACSL1, ALDH2, CYP27A1 and PPARA, demonstrating a good ability for DCM and myocardial infarction prediction. PPARA was positively correlated with adaptive immunocytes. Thirty-five drugs are candidate therapeutic targets.Conclusion
A nomogram and new biological targets for early diagnosis and treatment of DCM and myocardial infarction were provided.
SUBMITTER: Huang B
PROVIDER: S-EPMC10088053 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Publications
Identification of shared fatty acid metabolism related signatures in dilated cardiomyopathy and myocardial infarction.
Future science OA 20230328 3
<h4>Aim</h4>It is to be elucidated the risk-predictive role of differentially expressed fatty acid metabolism related genes (DE-FRGs) in dilated cardiomyopathy (DCM) and myocardial infarction.<h4>Materials & methods</h4>Four gene enrichment analyses defined DE-FRGs' biological functions and pathways. Three strategies were applied to identify risk biomarkers and construct a nomogram. The 4-DE-FRG correlation with immune cell infiltration, drugs, and ceRNA was explored.<h4>Results</h4>DE-FRGs were ...[more]