Transcriptomic Profiling of Subcutaneous Adipose Tissue in Relation to Bariatric Surgery: A Retrospective, Pooled Re-analysis.

ABSTRACT:

Background

Bariatric surgery is the most effective intervention for weight loss possibly through modulating subcutaneous adipose tissue (SAT) molecular programs. The post-operative molecular and biological impacts, including gene expression, deserve in-depth investigation especially given the small sample sizes in the literature.

Methods

Five existing datasets (n=237 SATs) were re-processed and corrected for batch-to-batch variation. Unsupervised approaches and robust linear mixed effect model were used to compare gene expression post- (n=126) to pre-operation (n=111).

Results

Post-operative SATs showed distinct global gene expression. Forty-four and 395 genes were over- and under-expressed post-operation (all Bonferroni P<0.05). The under-expressed genes signi

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10088552 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature