Self-powered, light-controlled, bioresorbable platforms for programmed drug delivery.

ABSTRACT: Degradable polymer matrices and porous scaffolds provide powerful mechanisms for passive, sustained release of drugs relevant to the treatment of a broad range of diseases and conditions. Growing interest is in active control of pharmacokinetics tailored to the needs of the patient via programmable engineering platforms that include power sources, delivery mechanisms, communication hardware, and associated electronics, most typically in forms that require surgical extraction after a period of use. Here we report a light-controlled, self-powered technology that bypasses key disadvantages of these systems, in an overall design that is bioresorbable. Programmability relies on the use of an external light source to illuminate an implanted, wavelength-sensitive phototransistor to trigger a shor

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10089205 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature