Virulence regulation of Zn²⁺ uptake system znuABC on mesophilic Aeromonas salmonicida SRW-OG1.

ABSTRACT: Psychrophilic Aeromonas salmonicida could not grow above 25°C and therefore thought unable to infect mammals and humans. In our previous study, a mesophilic A. salmonicida SRW-OG1 was isolated from Epinephelus coioides with furunculosis. Through the analysis of preliminary RNA-seq, it was found that the Zn²⁺ uptake related genes znuA, znuB and znuC might be involved in the virulence regulation of A. salmonicida SRW-OG1. Therefore, the purpose of this study was to explore the effect of znuABC silencing on the virulence regulation of A. salmonicida SRW-OG1. The results showed that the growth of the znuA-RNAi, znuB-RNAi, and znuC-RNAi strains was severely restricted under the Fe²⁺ starvation, bu

SUBMITTER: Wang J 

PROVIDER: S-EPMC10090552 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature