Regional Precuneus Cortical Hyperexcitability in Alzheimer's Disease Patients.

ABSTRACT:

Objective

Neuronal excitation/inhibition (E/I) imbalance is a potential cause of neuronal network malfunctioning in Alzheimer's disease (AD), contributing to cognitive dysfunction. Here, we used a novel approach combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to probe cortical excitability in different brain areas known to be directly involved in AD pathology.

Methods

We performed TMS-EEG recordings targeting the left dorsolateral prefrontal cortex (l-DLPFC), the left posterior parietal cortex (l-PPC), and the precuneus (PC) in a large sample of patients with mild-to-moderate AD (n = 65) that were compared with a group of age-matched healthy controls (n = 21).

Results

We found that patients with AD are characterized by a regional cor

SUBMITTER: Casula EP 

PROVIDER: S-EPMC10092632 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature