Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease.

ABSTRACT: The concept of senescence as a phenomenon limited to proliferating cells has been challenged by growing evidence of senescence-like features in terminally differentiated cells, including neurons. The persistence of senescent cells late in life is associated with tissue dysfunction and increased risk of age-related disease. We found that Alzheimer's disease (AD) brains have significantly higher proportions of neurons that express senescence markers, and their distribution indicates bystander effects. AD patient-derived directly induced neurons (iNs) exhibit strong transcriptomic, epigenetic, and molecular biomarker signatures, indicating a specific human neuronal senescence-like state. AD iN single-cell transcriptomics revealed that senescent-like neurons face oncogenic challenges and metab

SUBMITTER: Herdy JR 

PROVIDER: S-EPMC10093780 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature