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Faecal Microbiota Transplantation, Paving the Way to Treat Non-Alcoholic Fatty Liver Disease.


ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent cause of chronic liver disease (CLD). Currently, the only therapeutic recommendation available is a lifestyle change. However, adherence to this approach is often difficult to guarantee. Alteration of the microbiota and an increase in intestinal permeability seem to be key in the development and progression of NAFLD. Therefore, the manipulation of microbiota seems to provide a promising therapeutic strategy. One way to do so is through faecal microbiota transplantation (FMT). Here, we summarize the key aspects of FMT, detail its current indications and highlight the most recent advances in NAFLD.

SUBMITTER: Del Barrio M 

PROVIDER: S-EPMC10094628 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Faecal Microbiota Transplantation, Paving the Way to Treat Non-Alcoholic Fatty Liver Disease.

Del Barrio María M   Lavín Lucía L   Santos-Laso Álvaro Á   Arias-Loste Maria Teresa MT   Odriozola Aitor A   Rodriguez-Duque Juan Carlos JC   Rivas Coral C   Iruzubieta Paula P   Crespo Javier J  

International journal of molecular sciences 20230324 7


Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent cause of chronic liver disease (CLD). Currently, the only therapeutic recommendation available is a lifestyle change. However, adherence to this approach is often difficult to guarantee. Alteration of the microbiota and an increase in intestinal permeability seem to be key in the development and progression of NAFLD. Therefore, the manipulation of microbiota seems to provide a promising therapeutic strategy. One way to do  ...[more]

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