The relationship between obstructive sleep apnea and circulating tau levels: A meta-analysis.

ABSTRACT:

Background

Alzheimer's disease (AD) is an irreversible, progressive brain disorder that impairs memory, thinking, language, and, eventually, the ability to carry out the simplest of tasks. Tau protein, the major component of neurofibrillary tangles, is considered a key mediator of AD pathogenesis. The association between obstructive sleep apnea (OSA) and circulating tau remains unclear. The aim of the present meta-analysis was to evaluate the relationship between OSA and circulating tau via quantitative analysis.

Methods

A systematic search of Pubmed, Embase, and Web of Science were performed. The mean values of circulating total tau (T-tau) and phosphorylated tau (P-tau) in OSA and control groups were extracted. Standardized mean difference (SMD) with 95% confidence interva

SUBMITTER: Huang ZW 

PROVIDER: S-EPMC10097049 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature