Causal effect of psychiatric disorders on epilepsy: A two-sample Mendelian randomization study.

ABSTRACT:

Background

This study aims to explore the relationship between psychiatric disorders and the risk of epilepsy using Mendelian randomization (MR) analysis.

Methods

We collected summary statistics of seven psychiatric traits from recent largest genome-wide association study (GWAS), including major depressive disorder (MDD), anxiety disorder, autism spectrum disorder (ASD), bipolar disorder (BIP), attention deficit hyperactivity disorder (ADHD), schizophrenia (SCZ), and insomnia. Then, MR analysis estimates were performed based on International League Against Epilepsy (ILAE) consortium data (n_case  = 15,212 and n_control  = 29,677), the results of which were subsequently validated in FinnGen consortium (n_case  = 6260 and n_control  = 17

SUBMITTER: Li G 

PROVIDER: S-EPMC10097067 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature