Treatment changes in hemophilia A with chromogenic factor VIII assay implementation.

ABSTRACT:

Background

The one-stage assay (OSA) and the chromogenic assay (CSA) are 2 factor VIII (FVIII) assays used for the diagnosis and classification of hemophilia A. Discrepancies between the 2 assays exist in approximately one-third of patients with mild hemophilia A.

Objectives

The objectives of this study were to report the proportion of patients with mild or moderate hemophilia A and OSA-CSA discrepancies and to report the observed changes in treatment approach prompted by the presence of assay discrepancy. The study aimed to identify OSA:CSA ratio associated with the highest sensitivity for identification of patients in whom modification of treatment approach may be recommended.

Methods

This is a retrospective cohort study including adult (>18-year-old) patients with

SUBMITTER: Al Moosawi M 

PROVIDER: S-EPMC10099308 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature