Access to N-CF₃ Formamides by Reduction of N-CF₃ Carbamoyl Fluorides.

ABSTRACT: The departure into unknown chemical space is essential for the discovery of new properties and function. We herein report the first synthetic access to N-trifluoromethylated formamides. The method involves the reduction of bench-stable NCF₃ carbamoyl fluorides and is characterized by operational simplicity and mildness, tolerating a broad range of functional groups as well as stereocenters. The newly made N-CF₃ formamide motif proved to be highly robust and compatible with diverse chemical transformations, underscoring its potential as building block in complex functional molecules.

SUBMITTER: Zivkovic FG 

PROVIDER: S-EPMC10099374 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature