Association of time-to-intravenous furosemide with mortality in acute heart failure: data from REPORT-HF.

ABSTRACT:

Aim

Acute heart failure can be a life-threatening medical condition. Delaying administration of intravenous furosemide (time-to-diuretics) has been postulated to increase mortality, but prior reports have been inconclusive. We aimed to evaluate the association between time-to-diuretics and mortality in the international REPORT-HF registry.

Methods and results

We assessed the association of time-to-diuretics within the first 24 h with in-hospital and 30-day post-discharge mortality in 15 078 patients from seven world regions in the REPORT-HF registry. We further tested for effect modification by baseline mortality risk (ADHERE risk score), left ventricular ejection fraction (LVEF) and region. The median time-to-diuretics was 67 (25th-75th percentiles 17-190) min. Women, patie

SUBMITTER: Ouwerkerk W 

PROVIDER: S-EPMC10099670 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature