Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial.

ABSTRACT:

Importance

Although furosemide is the most commonly used loop diuretic in patients with heart failure, some studies suggest a potential benefit for torsemide.

Objective

To determine whether torsemide results in decreased mortality compared with furosemide among patients hospitalized for heart failure.

Design, setting, and participants

TRANSFORM-HF was an open-label, pragmatic randomized trial that recruited 2859 participants hospitalized with heart failure (regardless of ejection fraction) at 60 hospitals in the United States. Recruitment occurred from June 2018 through March 2022, with follow-up through 30 months for death and 12 months for hospitalizations. The final date for follow-up data collection was July 2022.

Interventions

Loop diuretic strategy of tor

SUBMITTER: Mentz RJ 

PROVIDER: S-EPMC9857435 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature