Association between soluble neprilysin and diabetes: Findings from a prospective longitudinal study.

ABSTRACT:

Background

The potential role of neprilysin (NEP) in glucose metabolism has been found by basic studies but lacks population evidence. The objective of this study was to examine the association between serum NEP and diabetes in Chinese adults.

Methods

In a prospective longitudinal cohort study - the Gusu cohort (n=2,286, mean age: 52 years, 61.5% females), the cross-sectional, longitudinal, and prospective associations between serum NEP and diabetes were systemically examined by logistic regression adjusting for conventional risk factors. Serum NEP was measured at baseline using commercial ELISA assays. Fasting glucose was repeatedly measured 4 years apart.

Results

The cross-sectional analysis found a positive association between serum NEP and fasting glucose at basel

SUBMITTER: Hu J 

PROVIDER: S-EPMC10100928 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature