Hypercapsule is the cornerstone of Klebsiella pneumoniae in inducing pyogenic liver abscess.

ABSTRACT:

Purpose

To investigate the mechanisms of Klebsiella pneumoniae-induced pyogenic liver abscess (PLA).

Methods

Forty-three K. pneumoniae strains from PLAs and 436 from non-PLAs were collected. Their differences were compared for virulence genes and factors, sequence types, and serotypes. Virulence genes wzi, wzy-K1, and wzi+wzy-K1 were deleted in K. pneumoniae NTUH-K2044. Various analyses, such as transmission electron microscopy, neutrophil killing tests, and mouse lethality tests, were used to confirm the consequent changes.

Results

Differences were found between K. pneumoniae strains from PLA and non-PLA samples for virulence genes and factors, including metabolism genes (allS and peg-344), capsula

SUBMITTER: Hu D 

PROVIDER: S-EPMC10102340 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature