Dataset Information

Dynamic chromatin architectures provide insights into the genetics of cattle myogenesis.

ABSTRACT:

Background

Sharply increased beef consumption is propelling the genetic improvement projects of beef cattle in China. Three-dimensional genome structure is confirmed to be an important layer of transcription regulation. Although genome-wide interaction data of several livestock species have already been produced, the genome structure states and its regulatory rules in cattle muscle are still limited.

Results

Here we present the first 3D genome data in Longissimus dorsi muscle of fetal and adult cattle (Bos taurus). We showed that compartments, topologically associating domains (TADs), and loop undergo re-organization and the structure dynamics were consistent with transcriptomic divergence during muscle development. Furthermore, we annotated cis-regulatory elements in cattle genome during myogenesis and demonstrated the enrichments of promoter and enhancer in selection sweeps. We further validated the regulatory function of one HMGA2 intronic enhancer near a strong sweep region on primary bovine myoblast proliferation.

Conclusions

Our data provide key insights of the regulatory function of high order chromatin structure and cattle myogenic biology, which will benefit the progress of genetic improvement of beef cattle.

SUBMITTER: Cheng J

PROVIDER: S-EPMC10103417 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Dynamic chromatin architectures provide insights into the genetics of cattle myogenesis.

Cheng Jie J Cao Xiukai X Wang Xiaogang X Wang Jian J Yue Binglin B Sun Wei W Huang Yongzhen Y Lan Xianyong X Ren Gang G Lei Chuzhao C Chen Hong H

Journal of animal science and biotechnology 20230414 1

<h4>Background</h4>Sharply increased beef consumption is propelling the genetic improvement projects of beef cattle in China. Three-dimensional genome structure is confirmed to be an important layer of transcription regulation. Although genome-wide interaction data of several livestock species have already been produced, the genome structure states and its regulatory rules in cattle muscle are still limited.<h4>Results</h4>Here we present the first 3D genome data in Longissimus dorsi muscle of f ...[more]

PMID: 37055796

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Dataset Information

Dynamic chromatin architectures provide insights into the genetics of cattle myogenesis.

Background

Results

Conclusions

Publications

Dynamic chromatin architectures provide insights into the genetics of cattle myogenesis.

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