Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever.

ABSTRACT:

Background

Typical symptoms of uncomplicated dengue fever (DF) include headache, muscle pains, rash, cough, and vomiting. A proportion of cases progress to severe dengue hemorrhagic fever (DHF), associated with increased vascular permeability, thrombocytopenia, and hemorrhages. Progression to severe dengue is difficult to diagnose at the onset of fever, which complicates patient triage, posing a socio-economic burden on health systems.

Methods

To identify parameters associated with protection and susceptibility to DHF, we pursued a systems immunology approach integrating plasma chemokine profiling, high-dimensional mass cytometry and peripheral blood mononuclear cell (PBMC) transcriptomic analysis at the onset of fever in a prospective study conducted in Indonesia.

Result

SUBMITTER: Ioannidis LJ 

PROVIDER: S-EPMC10103532 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature