GINS4 suppresses ferroptosis by antagonizing p53 acetylation with Snail.

ABSTRACT: Ferroptosis is an iron-dependent oxidative, nonapoptotic form of regulated cell death caused by the destruction of redox homeostasis. Recent studies have uncovered complex cellular networks that regulate ferroptosis. GINS4 is a promoter of eukaryotic G₁/S_-cell cycle as a regulator of initiation and elongation of DNA replication, but little is known about its impact on ferroptosis. Here, we found that GINS4 was involved in the regulation of ferroptosis in lung adenocarcinoma (LUAD). CRISPR/Cas9-mediated GINS4 KO facilitated ferroptosis. Interestingly, depletion of GINS4 could effectively induce G1, G₁/S, S, and G₂/M cells to ferroptosis, especially for G2/M cells. Mechanistically, GINS4 suppressed p53 stability through activating Snail that antago

SUBMITTER: Chen L 

PROVIDER: S-EPMC10104543 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature