GINS4 suppresses ferroptosis by antagonizing p53 acetylation with Snail
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Yongguang Tao
PROVIDER: PXD040993 | iProX | Tue Mar 21 00:00:00 GMT 2023
REPOSITORIES: iProX
Publications
GINS4 suppresses ferroptosis by antagonizing p53 acetylation with Snail.
Chen Ling L Cai Qidong Q Yang Rui R Wang Haiyan H Ling Huli H Li Tiansheng T Liu Na N Wang Zuli Z Sun Jingyue J Tao Tania T Shi Ying Y Cao Ya Y Wang Xiang X Xiao Desheng D Liu Shuang S Tao Yongguang Y
Proceedings of the National Academy of Sciences of the United States of America 20230405 15
Ferroptosis is an iron-dependent oxidative, nonapoptotic form of regulated cell death caused by the destruction of redox homeostasis. Recent studies have uncovered complex cellular networks that regulate ferroptosis. GINS4 is a promoter of eukaryotic G<sub>1</sub>/S<sub>-</sub>cell cycle as a regulator of initiation and elongation of DNA replication, but little is known about its impact on ferroptosis. Here, we found that GINS4 was involved in the regulation of ferroptosis in lung adenocarcinoma ...[more]
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