Dataset Information

Predictive factors of delayed viral clearance of asymptomatic Omicron-related COVID-19 screened positive in patients with cancer receiving active anticancer treatment.

ABSTRACT:

Objectives

We sought to identify the predictors of delayed viral clearance in patients with cancer with asymptomatic COVID-19 when the SARS-CoV-2 Omicron variants prevailed in Hong Kong.

Methods

All patients with cancer who were attending radiation therapy for head and neck malignancies or systemic anticancer therapy saved their deep throat saliva or nasopharyngeal swabs at least twice weekly for SARS-CoV-2 screening between January 1 and April 30, 2022. The multivariate analyses identified predictors of delayed viral clearance (or slow recovery), defined as >21 days for the cycle threshold values rising to ≥30 or undetectable in two consecutive samples saved within 72 hours. Three machine learning algorithms evaluated the prediction performance of the predictors.

Results

A total of 200 (15%) of 1309 patients tested positive for SARS-CoV-2. Age >65 years (P = 0.036), male sex (P = 0.003), high Charlson comorbidity index (P = 0.042), lung cancer (P = 0.018), immune checkpoint inhibitor (P = 0.036), and receipt of one or no dose of COVID-19 vaccine (P = 0.003) were significant predictors. The three machine learning algorithms revealed that the mean ± SD area-under-the-curve values predicting delayed viral clearance with the cut-off cycle threshold value ≥30 was 0.72 ± 0.11.

Conclusion

We identified subgroups with delayed viral clearance that may benefit from targeted interventions.

SUBMITTER: Lee VH

PROVIDER: S-EPMC10105908 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Predictive factors of delayed viral clearance of asymptomatic Omicron-related COVID-19 screened positive in patients with cancer receiving active anticancer treatment.

Lee Victor Ho-Fun VH Chan Sik-Kwan SK Tam Yiu-Ho YH Chau Tin-Ching TC Chan Jasper Fuk Woo JFW Chan Sum-Yin SY Ip Chun-Yat CY Choi Horace Cheuk-Wai HC Ng Sherry Chor-Yi SC Yuen Kwok Keung KK

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20230416

<h4>Objectives</h4>We sought to identify the predictors of delayed viral clearance in patients with cancer with asymptomatic COVID-19 when the SARS-CoV-2 Omicron variants prevailed in Hong Kong.<h4>Methods</h4>All patients with cancer who were attending radiation therapy for head and neck malignancies or systemic anticancer therapy saved their deep throat saliva or nasopharyngeal swabs at least twice weekly for SARS-CoV-2 screening between January 1 and April 30, 2022. The multivariate analyses ...[more]

PMID: 37072051

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Dataset Information

Predictive factors of delayed viral clearance of asymptomatic Omicron-related COVID-19 screened positive in patients with cancer receiving active anticancer treatment.

Objectives

Methods

Results

Conclusion

Publications

Predictive factors of delayed viral clearance of asymptomatic Omicron-related COVID-19 screened positive in patients with cancer receiving active anticancer treatment.

Similar Datasets

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