High co-expression of SLC7A11 and GPX4 as a predictor of platinum resistance and poor prognosis in patients with epithelial ovarian cancer.

ABSTRACT:

Objective

The aim was to assess the expression levels of SLC7A11 and GPX4 in relation to platinum resistance and prognosis in patients with epithelial ovarian cancer (EOC).

Design

A retrospective cohort study.

Setting

Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Population or sample

We included 192 eligible patients from hospital between January 2002 and December 2018.

Methods

We retrospectively analysed the medical records of patients with EOC. Surgical specimens of EOC were stained for SLC7A11 and GPX4. Survival analysis was performed using the Kaplan-Meier and Cox regression methods.

Main outcome measures

Clinical end points include platinum-free interval (PFI), progression-free survival (PFS) and overall survival

SUBMITTER: Wu X 

PROVIDER: S-EPMC10108211 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature