Research Review: A guide to computing and implementing polygenic scores in developmental research.

ABSTRACT: The increasing availability of genotype data in longitudinal population- and family-based samples provides opportunities for using polygenic scores (PGS) to study developmental questions in child and adolescent psychology and psychiatry. Here, we aim to provide a comprehensive overview of how PGS can be generated and implemented in developmental psycho(patho)logy, with a focus on longitudinal designs. As such, the paper is organized into three parts: First, we provide a formal definition of polygenic scores and related concepts, focusing on assumptions and limitations. Second, we give a general overview of the methods used to compute polygenic scores, ranging from the classic approach to more advanced methods. We include recommendations and reference resources available to researchers aimi

SUBMITTER: Allegrini AG 

PROVIDER: S-EPMC10108570 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature