Qualitative study on diabetic cutaneous wound healing with radiation crosslinked bilayer collagen scaffold in rat model.

ABSTRACT: Diabetes may leave patients more prone to skin problems, and minor skin conditions can more easily turn into serious damage to the extracellular matrix, which further impairs the skin's mechanical properties and delays wound healing. Therefore, the aim of the work is to develop extracellular matrix substitution to remodel the mechanical properties of diabetic cutaneous wound and thus accelerate diabetic wound healing. A green fabrication approach was used to prepare radiation crosslinked bilayer collagen scaffold from collagen dispersion. The morphological, mechanical and swelling characteristics of radiation crosslinked bilayer collagen scaffold were assessed to be suitable for cutaneous wound remodeling. The feasibility of radiation crosslinked bilayer collagen scaffold was performed on

SUBMITTER: Li H 

PROVIDER: S-EPMC10115801 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature