Hepatocellular carcinoma surveillance based on the Australian Consensus Guidelines: a health economic modelling study.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is the fastest increasing cause of cancer death in Australia. A recent Australian consensus guidelines recommended HCC surveillance for cirrhotic patients and non-cirrhotic chronic hepatitis B (CHB) patients at gender and age specific cut-offs. A cost-effectiveness model was then developed to assess surveillance strategies in Australia.

Methods

A microsimulation model was used to evaluate three strategies: biannual ultrasound, biannual ultrasound with alpha-fetoprotein (AFP) and no formal surveillance for patients having one of the conditions: non-cirrhotic CHB, compensated cirrhosis or decompensated cirrhosis. One-way and probabilistic sensitivity analyses as well as scenario and threshold analyses were conducted to account for unce

SUBMITTER: Nguyen ALT 

PROVIDER: S-EPMC10116722 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature