Intermittent hypoxia-induced enhancement of sociability and working memory associates with CNTNAP2 upregulation.

ABSTRACT:

Introduction

Hypoxia is an environmental risk factor for many disorders throughout life. Perinatal hypoxia contributes to autism spectrum disorder (ASD), while hypoxic conditions in the elderly facilitate memory deficits. However, the effects of hypoxia on adolescence remains elusive. CNTNAP2 is a critical molecule in ASD pathogenesis with undefined mechanisms. We investigate hypoxia's impact on adolescence and the underlying mechanism related to CNTNAP2.

Methods

Three-chamber social approach test, Y maze, Morris Water Maze and Open Field Test were applied to evaluate behavioral alterations. Immunoblotting, 5'- RACE and dual-luciferase reporter assay were performed to examine CNTNAP2 protein expression, transcription start site (TSS) of human CNTNAP2 gene and CNTNAP2 promote

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC10118049 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature