Association of asthma genetic variants with asthma-associated traits reveals molecular pathways of eosinophilic asthma.

ABSTRACT:

Introduction

Asthma is a complex, polygenic, heterogenous inflammatory disease. Recently, we generated a list of 128 independent single nucleotide polymorphisms (SNPs) associated with asthma in genome-wide association studies. However, it is unknown if asthma SNPs are associated with specific asthma-associated traits such as high eosinophil counts, atopy, and airway obstruction, revealing molecular endotypes of this disease. Here, we aim to identify the association between asthma SNPs and asthma-associated traits and assess expression quantitative trait locus (e-QTLs) to reveal their downstream functional effects and find drug targets.

Methods

Association analyses between 128 asthma SNPs and associated traits (blood eosinophil numbers, atopy, airway obstruction, airway hyper

SUBMITTER: El-Husseini ZW 

PROVIDER: S-EPMC10119226 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature