Ontology highlight
ABSTRACT: Objective
Post-acute sequelae of SARS-COV-2 (PASC) are emerging as a major health challenge. Orthostatic intolerance secondary to autonomic failure has been found in PASC patients. This study investigated the effect of COVID-19 after recovery on blood pressure (BP) during the orthostatic challenge.Research design and methods
Thirty-one out of 45 patients hospitalized due to COVID-19-related pneumonia that developed PASC and did not have hypertension at discharge were studied. They underwent a head-up tilt test (HUTT) at 10.8 ± 1.9 months from discharge. All met the PASC clinical criteria, and an alternative diagnosis did not explain the symptoms. This population was compared with 32 historical asymptomatic healthy controls.Results
Exaggerated orthostatic blood pressure response (EOPR)/orthostatic hypertension (OHT) was detected in 8 out of 23 (34.7 %) patients, representing a significantly increased prevalence (7.67-fold increase p = 0.009) compared to 2 out of 32 (6.4 %) asymptomatic healthy controls matched by age, who underwent HUTT and were not infected with SARS-CoV-2.Conclusions
This prospective evaluation in patients with PASC revealed abnormal blood pressure rise during the orthostatic challenge, suggesting of autonomic dysfunction in a third of the studied subjects. Our findings support the hypothesis that EOPR/OHT may be a phenotype of neurogenic hypertension. Hypertension in PASC patients may adversely affect the cardiovascular burden in the world.
SUBMITTER: Gonzalez-Hermosillo G JA
PROVIDER: S-EPMC10121145 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
González-Hermosillo G J Antonio JA Galarza Esteban Jorge EJ Fermín Onasis Vicente OV González José Manuel Núñez JMN Tostado Lucia Mariel Félix Álvarez LMFÁ Lozano Marco Antonio Estrada MAE Rabasa Claudia Ruíz CR Martínez Alvarado María Del Rocio MDR
Autonomic neuroscience : basic & clinical 20230421
<h4>Objective</h4>Post-acute sequelae of SARS-COV-2 (PASC) are emerging as a major health challenge. Orthostatic intolerance secondary to autonomic failure has been found in PASC patients. This study investigated the effect of COVID-19 after recovery on blood pressure (BP) during the orthostatic challenge.<h4>Research design and methods</h4>Thirty-one out of 45 patients hospitalized due to COVID-19-related pneumonia that developed PASC and did not have hypertension at discharge were studied. The ...[more]