Adipocyte-derived chemerin rescues lipid overload-induced cardiac dysfunction.

ABSTRACT: Chemerin, an adipocyte-secreted protein, has been recently suggested to be linked to metabolic syndrome and cardiac function in obese and diabetes mellitus. This study aimed to investigate the potential roles of adipokine chemerin on high fat-induced cardiac dysfunction. Chemerin (Rarres2) knockout mice, which were fed with either a normal diet or a high-fat diet for 20 weeks, were employed to observe whether adipokine chemerin affected lipid metabolism, inflammation, and cardiac function. Firstly, we found normal metabolic substrate inflexibility and cardiac function in Rarres2 ^-/- mice with a normal diet. Notably, in a high-fat diet, Rarres2 ^-/- mice showed lipotoxicity, insulin resistance, and inflammation, thus causing metabolic

SUBMITTER: Liu R 

PROVIDER: S-EPMC10121453 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature