Dataset Information
Comparison of alternative splicing (AS) events in adipose tissue of polled dorset versus small tail han sheep.
Ontology highlight
ABSTRACT: Background
During the alternative splicing (AS), the exons of primary transcripts are spliced in various arrangements, resulting in structurally and functionally distinct mRNAs and proteins. This study aimed to examine genes with AS events from Small Tail Han sheep and Dorset sheep to explore the mechanism of adipose developments.Methods
This study identified the genes with AS events in adipose tissues of two different sheep with next-generation sequencing. In this paper, genes with significantly different AS events were performed gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses.Results
364 genes with 411 A S events showed significant differences in adipose tissues between the two breeds; 108 genes with 120 A S events were extremely significant differences between the two breeds. We identified several novel genes that are related with adipose growth and development. The results of KEGG and GO analysis indicated that oocyte meiosis, mitogen-activated protein kinase (Wnt), mitogen-activated protein kinase (MAPK) signaling pathway, etc. Were closely related to the adipose tissue developments.Conclusions
This paper revealed that the genes with AS events are important for adipose tissues in sheep, exploring the mechanisms of AS events associated with adipose tissue developments in sheep of different breeds.
SUBMITTER: Miao X
PROVIDER: S-EPMC10121611 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Publications
Comparison of alternative splicing (AS) events in adipose tissue of polled dorset versus small tail han sheep.
Heliyon 20230331 4
<h4>Background</h4>During the alternative splicing (AS), the exons of primary transcripts are spliced in various arrangements, resulting in structurally and functionally distinct mRNAs and proteins. This study aimed to examine genes with AS events from Small Tail Han sheep and Dorset sheep to explore the mechanism of adipose developments.<h4>Methods</h4>This study identified the genes with AS events in adipose tissues of two different sheep with next-generation sequencing. In this paper, genes w ...[more]
