Ontology highlight
ABSTRACT:
SUBMITTER: Chamberland S
PROVIDER: S-EPMC10121938 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Chamberland Simon S Nebet Erica R ER Valero Manuel M Hanani Monica M Egger Robert R Larsen Samantha B SB Eyring Katherine W KW Buzsáki György G Tsien Richard W RW
Neuron 20230213 8
Neurons perform input-output operations that integrate synaptic inputs with intrinsic electrical properties; these operations are generally constrained by the brevity of synaptic events. Here, we report that sustained firing of CA1 hippocampal fast-spiking parvalbumin-expressing interneurons (PV-INs) can be persistently interrupted for several hundred milliseconds following brief GABA<sub>A</sub>R-mediated inhibition in vitro and in vivo. A single presynaptic neuron could interrupt PV-IN firing, ...[more]