Surgery After BRAF-Directed Therapy Is Associated with Improved Survival in BRAF^V600E Mutant Anaplastic Thyroid Cancer: A Single-Center Retrospective Cohort Study.

ABSTRACT: Background: The aim of this study was to describe the oncologic outcomes of patients with BRAF^V600E-mutated anaplastic thyroid cancer (ATC) who had neoadjuvant BRAF-directed therapy with subsequent surgery. For context, we also reviewed patients who received BRAF-directed therapy after surgery, and those who did not have surgery after BRAF-directed therapy. Methods: This was a single-center retrospective cohort study conducted at a tertiary care cancer center in Texas from 2017 to 2021. Fifty-seven consecutive patients with BRAF^V600E-mutated ATC and at least 1 month of BRAF-directed therapy were included. Primary outcomes were overall survival (OS) and progression-free survival (PFS). Results: All patients had stage IVB (35%)

SUBMITTER: Zhao X 

PROVIDER: S-EPMC10122263 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature